Peanut oleosins associated with severe peanut allergy—importance of lipophilic allergens for comprehensive allergy diagnostics

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Development of a Novel Strategy to Isolate Lipophilic Allergens (Oleosins) from Peanuts

BACKGROUND Peanut allergy is one of the most severe class I food allergies with increasing prevalence. Especially lipophilic allergens, such as oleosins, were found to be associated with severe symptoms, but are usually underrepresented in diagnostic extracts. Therefore, this study focused on isolation, molecular characterization and assessment of the allergenicity of peanut oleosins. METHODS...

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Benefits and limitations of molecular diagnostics in peanut allergy

Allergic reactions to peanut (Arachis hypogaea, Ara h) are caused by immunoglobulin E (IgE)-mediated sensitizations to various proteins. The stability and relative proportion of these proteins in peanut determine the risk of hazardous reactions. Hazardous sensitization to seed storage proteins [S2 albumins (Ara h 2, 6 and 7) > other seed storage proteins (Ara 1 and 3) > oleosins (Ara h 10 and 1...

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The prevalence of peanut allergy (PA) in Africa is unknown but anecdotal reports suggest the prevalence to be lower than that experienced in developed countries, which report a prevalence of approximately 1.5%. Countries in Africa and Asia, as well as Israel, where the early consumption of high-dose peanut protein is routinely practised, have enjoyed a low prevalence of peanut allergy, e.g. 0.0...

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ژورنال

عنوان ژورنال: Journal of Allergy and Clinical Immunology

سال: 2017

ISSN: 0091-6749

DOI: 10.1016/j.jaci.2017.02.020